![]() Read more information on the study design and analytic practices in the HACM Study. Through frequent updates of the data, investigators also monitor changing trends in cancer risk over time. Investigators compare different groups of people with HIV, to determine whether certain individuals are at especially high risk of cancer. The risk of cancer in people with HIV is compared with that in the general population to determine which cancers arise more frequently than expected. NCI researchers use these study data to determine the spectrum of cancers that occur in people with HIV. The NCI receives only anonymized data from these registries. The HACM Study is based on a series of computerized linkages between the databases (termed “registries”) that are maintained by state public health authorities. Note: This study does not recruit patients, and all identifiable information is removed from files used by researchers at NCI. ![]() The study has made important contributions to public health, including characterizing trends in cancer risk over the course of the entire HIV epidemic, understanding shifts in the projected cancer burden among aging populations on long-term antiretroviral therapy, and describing disparities in treatment and outcomes following a cancer diagnosis. The HACM Study focuses on the modern era of effective antiretroviral therapy starting in 1996 through the present time. Health departments merge their disease-specific registries to construct a new database resource through which to study cancer risk among people with HIV. The study uses public health surveillance information on people with HIV and cancer, both of which are notifiable conditions to health departments. One of the largest studies of cancer in people with HIV, the HACM Study is a long-standing collaboration between the National Cancer Institute (NCI) and state health departments. The HIV/AIDS Cancer Match Study (HACM) is an observational study of over 850,000 people with HIV across multiple regions of the United States. Eric Engels, Meredith Shiels, and Qianlai LuoĮric A.
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